## Abstract The Pictet‐Spengler reaction is performed as a one‐pot procedure by condensing thienylethylamine (I) with carbonyl compounds (II), followed by treatment of the in situ formed imines with acetic‐formic anhydride (III) to produce a formyliminium ion, which upon treatment with TFA cyclizes
✦ LIBER ✦
ChemInform Abstract: A Simple and Efficient Large-Scale Synthesis of 3-Hydroxyphthalans via Oxa-Pictet—Spengler Reaction Catalyzed by Nanosilica Sulfuric Acid.
✍ Scribed by Zahra Khorsandi; Ahmad Reza Khosropour; Valiollah Mirkhani; Iraj Mohammadpoor-Baltork; Majid Moghadam; Shahram Tangestaninejad
- Publisher
- John Wiley and Sons
- Year
- 2011
- Weight
- 34 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0931-7597
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✦ Synopsis
Abstract
The condensation of benzyl alcohols (I) with aromatic aldehydes under conventional heating or microwave conditions affords the target compounds (18 examples) with generally good to excellent yields within a short time.
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