A short synthesis of the parp inhibitor
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Steven C. Austen; John M. Kane
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Article
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2001
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Journal of Heterocyclic Chemistry
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English
⚖ 26 KB
## Abstract A four‐step synthesis of the PARP inhibitor 2‐(4‐trifluoromethylphenyl)benzimidazole‐4‐carboxamide (1, NU1077) is presented. Condensation of 2,3‐diaminotoluene and 4‐trifluoromethylbenzaldehyde afforded 4‐methyl‐2‐(4‐trifluoromethylphenyl)benzimidazole. Oxidation of the methyl group wit