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ChemInform Abstract: A Short Synthesis of the PARP Inhibitor 2-(4-Trifluoromethylphenyl)benzimidazole-4-carboxamide (NU1077) (V).

✍ Scribed by Steven C. Austen; John M. Kane


Publisher
John Wiley and Sons
Year
2010
Weight
27 KB
Volume
32
Category
Article
ISSN
0931-7597

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A short synthesis of the parp inhibitor
✍ Steven C. Austen; John M. Kane 📂 Article 📅 2001 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 26 KB

## Abstract A four‐step synthesis of the PARP inhibitor 2‐(4‐trifluoromethylphenyl)benzimidazole‐4‐carboxamide (1, NU1077) is presented. Condensation of 2,3‐diaminotoluene and 4‐trifluoromethylbenzaldehyde afforded 4‐methyl‐2‐(4‐trifluoromethylphenyl)benzimidazole. Oxidation of the methyl group wit