ChemInform Abstract: A Short, Efficient Synthesis of Substituted Uracil: An Indane Carbocyclic Nucleoside.
β Scribed by Franco Fernandez; Xerardo Garcia-Mera; Melvin Morales; Jose E. Rodriguez-Borges
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 29 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0931-7597
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A Slightly Shorter Route to Carbocyclic Nucleosides. Synthesis of (Β±)-trans-1-[2-(Hydroxymethyl)cyclopentylmethyl]uracil. -Nucleoside analogue (VIII) is synthesized by constructing the uracil base around the amino alcohol precursor (VI). Isocyanate (V) is equally suitable for formation of the base