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ChemInform Abstract: A Short and Unequivocal Synthesis of 5-Aminotetrazolo[1,5-a]quinazoline as a Tricyclic Analogue of 4-(3-Bromoanilino)-6,7-dimethoxyquinazoline (PD 153035).

✍ Scribed by E. BENCTEUX; R. HOUSSIN; J.-P. HENICHART


Book ID
101852897
Publisher
John Wiley and Sons
Year
2010
Weight
32 KB
Volume
29
Category
Article
ISSN
0931-7597

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A short and unequivocal synthesis of 5-a
✍ Edith Bencteux; Raymond Houssin πŸ“‚ Article πŸ“… 1997 πŸ› Journal of Heterocyclic Chemistry 🌐 English βš– 272 KB

## Abstract The discovery of 4‐(3‐bromoanilino)‐6,7‐dimethoxyquinazoline (PD 153035) as an extremely potent inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor led to the preparation of several fused tricyclic quinazoline analogues. The present paper reports a new tric