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ChemInform Abstract: A Regioselective SNAr Reaction of Poly-halo-quinoline-3-carboxylates with Phenol, Thiophenol, or N-Methylaniline.

✍ Scribed by Shikui Zhao; Weicheng Zhou

Publisher: John Wiley and Sons
Year: 2011
Weight: 65 KB
Volume: 42
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.201129142

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✦ Synopsis

Abstract

Polyhaloquinoline‐3‐carboxylates (I) and (VIII) react with phenols, thiophenols, or anilines highly regioselectively to give mono‐, di‐ or trisubstituted derivatives in dependence on educt ratio and reaction conditions.

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