ChemInform Abstract: A Rapid Assembly of Homochiral 2,3,4-Trisubstituted Pyrrolidines.

✍ Scribed by R. C. F. JONES; K. J. HOWARD; J. S. SNAITH

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 28 KB
• Volume: 28
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199725105

✦ Synopsis

25 -105

A Rapid Assembly of Homochiral 2,3,4-Trisubstituted Pyrrolidines.

-Homochiral dihydroimidazolium ylides, generated in situ from enantiopure imidazolines (I) and the bromoacetate (II) undergo intramolecular 1,3-dipolar cycloaddition to the tricyclic adduct (III). This is a valuable precursor of 2,3,4-trisubstituted chiral pyrrolidines such as (IV) and (V), potential building blocks in the field of neuroexcitatory compounds.

-(JONES, R. C. F.;