ChemInform Abstract: A Practical Synthesis of trans-3-Substituted Proline Derivatives Through 1,4-Addition.

✍ Scribed by Peter Huy; Joerg-Martin Neudoerfl; Hans-Guenther Schmalz

• Publisher: John Wiley and Sons
• Year: 2011
• Weight: 56 KB
• Volume: 42
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.201116204

✦ Synopsis

Abstract

A short synthesis of trans‐3‐substituted proline derivatives such as (VII) is accomplished by Cu‐catalyzed addition of Grignard reagents to dehydroproline esters (III).