ChemInform Abstract: A Practical Synthesis of 3-Chloro-α-bromostyrene Starting from 3-Chloroethylbenzene.

✍ Scribed by Ken Tanaka; Akemi Hosokawa; Yuichiro Tanigawa

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 29 KB
• Volume: 30
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199923103

✦ Synopsis

A Practical Synthesis of 3-Chloro-α-bromostyrene Starting from 3-Chloroethylbenzene.

-The reaction conditions for the bromination of derivative (I) to give product (II) and for the dehydrobromination of (II) to afford product (III) are optimized. The synthesis of (III), a key intermediate in the preparation of potent herbicide MK-243, can also be carried out as a one-pot procedure. -(TANAKA, KEN; HOSOKAWA, AKEMI; TANIGAWA,