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ChemInform Abstract: A Parallel Combinatorial Approach to Locating Homochiral Lewis Acid Catalysts for the Asymmetric Aza-Diels—Alder Reaction of an Imino Dienophile.

✍ Scribed by S. BROMIDGE; P. C. WILSON; A. WHITING

Publisher: John Wiley and Sons
Year: 2010
Weight: 31 KB
Volume: 30
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199909160

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✦ Synopsis

A Parallel Combinatorial Approach to Locating Homochiral Lewis Acid Catalysts for the Asymmetric Aza-Diels-Alder Reaction of an Imino Dienophile.

-Optimized conditions for the asymmetric aza-Diels-Alder reaction of Danishefsky's diene (I) and the imine (II) have been developed using parallel combinatorial methods. An enantiomeric access up to 97% is obtained using chiral 1,2-diphenylethylene diamine/ MgI 2 as catalyst.

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