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ChemInform Abstract: A Novel Synthesis of Benzo[c]phenanthridine Skeleton and Biological Evaluation of Isoquinoline Derivatives.

✍ Scribed by Won-Jea Cho; Myun-Ji Park; Takeshi Imanishi; Byung-Ho Chung

Publisher
John Wiley and Sons
Year
2010
Weight
31 KB
Volume
30
Category
Article
ISSN
0931-7597

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✦ Synopsis

A Novel Synthesis of Benzo[c]phenanthridine Skeleton and Biological Evaluation of Isoquinoline Derivatives.

-Most 3-arylisoquinolinones, such as (I), (II) and (IV), display strong activities against human tumor cell lines. The indenoisoquinolinone (V) exhibits excellent cytotoxicity. -(CHO,

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## Abstract The reactions of (VII), easily prepared starting from diester (I), with various N‐nucleophiles is studied.