ChemInform Abstract: A Novel Strategy for N-Alkylation of Primary Amines.

✍ Scribed by Sanjay k. Srivastava; Prem Man Singh Chauhan; Amiya P. Bhaduri

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 30 KB
• Volume: 30
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199935093

✦ Synopsis

A Novel Strategy for N-Alkylation of Primary Amines.

-The course of alkylation of aniline is dependent on the chain length of the alkyl bromide used. Under the reaction conditions (A) alkyl bromides with a number of carbon atoms ≤ 4 give dialkylanilines exclusively, whereas alkylbromides with a number of carbon atoms ≥ 6 give monoalkylanilines. With n-pentylbromide (IV) a mixture of mono-and dipentylaniline is obtained. Similar results are obtained with 4-fluoroaniline and cyclohexyl amine. -(SRIVASTAVA,