ChemInform Abstract: A Novel Construction of 2-Benzazepine Scaffold Based on TiCl4-Mediated Tandem Mannich Reaction — Aromatic Electrophilic Substitution.

A Novel Construction of 2-Benzazepine Sc

A Novel Construction of 2-Benzazepine Scaffold Based on TiCl4-Mediated Tandem Mannich Reaction–Aromatic Electrophilic Substitution

✍ Liangxi Li; Zhiming Li; Quanrui Wang 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 German ⚖ 187 KB

A novel construction of 2-benzazepine derivatives based on TiCl 4 -mediated tandem Mannich reaction of electron-rich benzyl iminium ions with alkenyl ethers and Friedel -Crafts-type alkylation is described. The protocol is amenable to provide the tricyclic furo [3,2-d][2]benzazepine and pyrano [3,2d