ChemInform Abstract: A Novel Approach Towards 2,3,5-Trisubstituted Thiophenes via Tandem Michael Addition/Intramolecular Knoevenagel Condensation.

✍ Scribed by D. OBRECHT; F. GERBER; D. SPRENGER; T. MASQUELIN

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 31 KB
• Volume: 28
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199723135

✦ Synopsis

A Novel Approach Towards 2,3,5-Trisubstituted Thiophenes via Tandem Michael Addition/Intramolecular Knoevenagel Condensation.

-The title reaction is applied to highly functionalized acetylenic ketones such as (III). In this reaction the mixture of Cs2CO3/MgSO4 is an efficient base for the cyclization to the novel trisubstituted thiophenes (V). These compounds serve as multifunctional building blocks because subsequent one-step transformations convert them into corresponding aldehydes, acids and alcohols. -(OBRECHT, D.;