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ChemInform Abstract: A New Entry to [1,2,4]Triazolo[1,5-a][1,4]benzodiazepin-6-ones via Intramolecular Nitrilimine Cycloaddition to the Cyano Group.

✍ Scribed by Gianluigi Broggini; Luisa Garanti; Giorgio Molteni; Gaetano Zecchi


Publisher
John Wiley and Sons
Year
2010
Weight
31 KB
Volume
30
Category
Article
ISSN
0931-7597

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✦ Synopsis


A New Entry to [1,2,4]Triazolo [1,5-a][1,4]benzodiazepin-6-ones via Intramolecular Nitrilimine Cycloaddition to the Cyano Group.

-A new methodology is presented for the synthesis of title benzodiazepinones (VIII), which are of potential pharmacological interest. Thus, employing nitrilimines, generated in situ by treatment of hydrazonoyl chlorides (VII) with silver carbonate, intramolecular cycloaddition of the nitrilimine moiety to the cyano group yields the targets (VIII). -(BROGGINI, GIANLUIGI;


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