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ChemInform Abstract: A New Cleavable Carbene-Generating Reagent with 3-Phenyl-3-trifluoromethyldiazirine Photophore.

✍ Scribed by Uwe Kempin; Yuichi Kanaoka; Yasumaru Hatanaka


Publisher
John Wiley and Sons
Year
2010
Weight
30 KB
Volume
30
Category
Article
ISSN
0931-7597

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## Abstract The synthesis of 2,3‐dihydroxy‐3‐{3‐[3‐(trifluoromethyl)diazirin‐3‐yl]phenyl}propionic acid (8), a new cleavable carbenegenerating reagent used in photocrosslinking experiments in molecular biology is described. This synthesis starts with the bromination of trifluoroacetophenone. The re