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ChemInform Abstract: A N-Nitrosochloroethyl-cephalosporin Carbamate Prodrug for Antibody- Directed Enzyme Prodrug Therapy (ADEPT).

✍ Scribed by R. P. ALEXANDER; R. W. BATES; A. J. PRATT; J. A. E. KRAUNSOE

Book ID
112035395
Publisher
John Wiley and Sons
Year
2010
Weight
31 KB
Volume
27
Category
Article
ISSN
0931-7597

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The synthesis of a novel enediyne 2, and its cytotoxicity and activation by the nitroreductase enzyme NR2 from Esherichia coli B, are described. In contrast to closely related analogues, 2 exhibits a 90-fold increase in cytotoxicity against UV4 cells in the presence of the enzyme and NADH, suggestin