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ChemInform Abstract: A Mild and Facile Reduction of Azides to Amines by N,N-Dimethylhydrazine and Catalytic Ferric Chloride.

โœ Scribed by A. KAMAL; B. S. N. REDDY

Publisher
John Wiley and Sons
Year
2010
Weight
33 KB
Volume
29
Category
Article
ISSN
0931-7597

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โœฆ Synopsis

A Mild and Facile Reduction of Azides to Amines by N,N-Dimethylhydrazine and Catalytic Ferric Chloride.

-A new and convenient method for the reduction of aryl and alkyl azides to the corresponding amines using N,N-dimethylhydrazine in the presence of catalytic amounts of FeCl 3 is described. This reductive system proves to be compatible with a wide variety of other reducible functional groups such as nitro, esters, carbonyl, amides, halo and benzyl ethers. Moreover, the usefulness of this reagent system is illustrated in the azido reductive cyclization of optically pure N-(o-azidobenzoyl)pyrrolidinecarbaldehyde (V). -(KAMAL, A.; REDDY, B.

๐Ÿ“œ SIMILAR VOLUMES

ChemInform Abstract: Iodotrimethylsilane
ChemInform Abstract: Iodotrimethylsilane: A Mild and Efficient Reagent for the Reduction of Azides to Amines.
โœ A. KAMAL; N. V. RAO; E. LAXMAN ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons โš– 29 KB ๐Ÿ‘ 2 views

Iodotrimethylsilane: A Mild and Efficient Reagent for the Reduction of Azides to Amines. -An efficient and chemoselective protocol for the reduction of azides using in situ prepared iodotrimethylsilane as a reducing agent is reported. The corresponding amines are formed in excellent yields. -