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ChemInform Abstract: A Highly Refined Version of the α-Keto Ester Based Carbapenem Synthesis: The Total Synthesis of Meropenem.

✍ Scribed by A. S. PRASHAD; N. VLAHOS; P. FABIO; G. B. FEIGELSON

Publisher: John Wiley and Sons
Year: 2010
Weight: 35 KB
Volume: 29
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199850281

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✦ Synopsis

A Highly Refined Version of the α-Keto Ester Based Carbapenem Synthesis: The Total Synthesis of Meropenem.

-An optimized strategy for the α-keto ester based synthesis of carbapenems is presented. Thus, acidic treatment of compound (I) allows the ring forming cyclization and deprotection to give meropenem (II) in a single step. The precursor (III) bearing acid-stable protecting groups gives under similar conditions the diprotected carbapenem (IV). -(PRASHAD, A.

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