✦ LIBER ✦
ChemInform Abstract: A Highly Efficient Synthesis of (-)-PI-091 Construction of the 4- Alkoxy-2-butene-4-lactam Skeleton from Fischer-Type Carbene Complexes, Alkynyllithiums, and Tosyl Isocyanate.
✍ Scribed by N. IWASAWA; K. MAEYAMA
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 35 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0931-7597
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✦ Synopsis
A Highly Efficient Synthesis of (-)-PI-091 Construction of the 4-Alkoxy-2-butene-4-lactam Skeleton from Fischer-Type Carbene Complexes, Alkynyllithiums, and Tosyl Isocyanate.
-A general and facile method for the construction of lactams such as ( IV) is developed by the reaction of the propargyl metallic species, generated from Fischer-type carbene complexes and alkynyllithiums, and tosyl isocyanate. Starting from (Ia) and (V) this approach is applied to an enantioselective synthesis of the title product (X). -(IWASAWA, N.;