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ChemInform Abstract: A General and Efficient Route to 6-Methyl-pyrazin-2-yl-amines: Alkylation of 2,6-Dichloropyrazine via Malonate Derivatives.

โœ Scribed by Paul J. J. Colbon; Alison C. Foster; Melvyn E. Giles; Zakariya Patel; John T. Singleton


Publisher
John Wiley and Sons
Year
2009
Weight
37 KB
Volume
40
Category
Article
ISSN
0931-7597

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A general and efficient route to 6-methy
โœ Paul J. J. Colbon; Alison C. Foster; Melvyn E. Giles; Zakariya Patel; John T. Si ๐Ÿ“‚ Article ๐Ÿ“… 2008 ๐Ÿ› Journal of Heterocyclic Chemistry ๐ŸŒ English โš– 424 KB

## Abstract magnified image We have developed a convenient twoโ€stage process for the synthesis of 6โ€methylpyrazineโ€2โ€ylโ€amines from commercially available materials. The procedure involves the synthesis of (6โ€chloroโ€pyrazinโ€2โ€yl)โ€acetic acid __via__ arylation of diethyl malonate and __in situ__ hy