ChemInform Abstract: A Facile Synthesis of 2-Substituted Isoflavones for Immunoassay: Assembly of the Isoflavonoid Skeleton by Means of a Novel Cyclization Reaction.

✍ Scribed by Andrew Pelter; Robert S. Ward; Jacqueline L. Whalley

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 31 KB
• Volume: 30
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199913163

✦ Synopsis

A Facile Synthesis of 2-Substituted Isoflavones for Immunoassay: Assembly of the Isoflavonoid Skeleton by Means of a Novel Cyclization Reaction.

-In connection with the development of immunoassays for wide-scale screening, isoflavones bearing a remote group attachable to a hapten are synthesized. The procedure involves a novel cyclization of the deoxybenzoins (II) to 2-alkylisoflavones via intermediate formation of a silyl enolate. Full deprotection of the methoxy groups leads to the target (V). -