## Abstract A facile and efficient synthetic methodo‐ logy for the preparation of diethyl α,α‐chlorofluoro‐ alkanephosphonates is described. A wide variety of diethyl α‐hydroxyphosphonates were investigated by a two‐step halogenation procedure, which includes nucleophilic chlorination with PPh~3~ a
✦ LIBER ✦
ChemInform Abstract: A Facile and Efficient Synthesis of Diethyl α,α-Chlorofluoroalkanephosphonates.
✍ Scribed by Zhi Guan; Di Wu; Jian-Ping Fu; Yan-Hong He
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 22 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0931-7597
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✦ Synopsis
Abstract
A wide range of α,α‐chlorofluoroalkanephosphonates (III) are synthesized via nucleophilic chlorination of corresponding α‐hydroxyphosphonates (I) followed by electrophilic fluorination.
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