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ChemInform Abstract: A Cycloisomerization/Friedel—Crafts Alkylation Strategy for the Synthesis of Pyrano[3,4-b]indoles.

✍ Scribed by Matthew R. Medeiros; Scott E. Schaus; John A. Jr. Porco

Publisher: John Wiley and Sons
Year: 2011
Weight: 38 KB
Volume: 42
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.201150116

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✦ Synopsis

Abstract

The two‐step procedure involves a Sonogashira coupling of dihydropyran propargyl ethers with iodoanilines or iodophenols according to A) followed by Sc(OTf)~3~‐catalyzed Friedel—Crafts alkylation.

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