ChemInform Abstract: A Convenient Transformation of 2-Alkylidenecycloalkanones into Alkyl-Substituted Bicyclo[n.1.0]alkan-1-ols: Application to the Synthesis of Capsaicin.
β Scribed by Dzmitry G. Kananovich; Dzmitry M. Zubrytski; Oleg G. Kulinkovich
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 63 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0931-7597
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β¦ Synopsis
Abstract
An efficient procedure is developed via conditions A) (formation of Ξ²βiodoketones) followed by conditions B) in the presence of either TmsCl or TiCl(OβiPr)~3~.
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A New Versatile Reagent for the Synthesis of Cyclopropylamines Including 4-Azaspiro(2.n)alkanes and Bicyclo(n.1.0)alkylamines. -The reaction of dialkylcarboxamides or the ester (IV) with equimolar ratios of Grignard reagents and methyltriisopropyloxytitanium gives cyclopropane derivatives in better