ChemInform Abstract: A Convenient Synthesis of N4,O3′,O5′-Triacetyl-2′-ketocytidine.

✍ Scribed by D. P. KJELL; B. J. SLATTERY

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 30 KB
• Volume: 28
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199741274

✦ Synopsis

A Convenient Synthesis of N4,O3',O5'-Triacetyl-2'-ketocytidine.

-A convenient and regioselective synthesis of the ketocytidine (VI) is presented. The synthesis includes an improved preparation of the arabino derivative (V) by differentiation of the 2'-position and ring opening to the arabino derivative (V). Dess-Martin oxidation affords the title ketocytidine compound in 31% overall yield. -(KJELL, D.