✦ LIBER ✦
ChemInform Abstract: A Concise Total Synthesis of (.+-.)-cis- and (.+-.)-trans-Clavicipitic Acids by Combinatorial Use of Directed Lithiation and Fluoride Ion- Induced Elimination-Addition Reaction of 1-(Triisopropylsilyl)gramine Derivatives.
✍ Scribed by M. IWAO; F. ISHIBASHI
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 33 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0931-7597
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✦ Synopsis
A Concise Total Synthesis of (±)-cis-and (±)-trans-Clavicipitic Acids by Combinatorial Use of Directed Lithiation and Fluoride Ion-Induced Elimination-Addition Reaction of 1-(Triisopropylsilyl)gramine Derivatives.
-The key steps in the synthesis of the title compounds (VIII) and (IX) are regioselective lithiation of the gramine (I) and formation of the diester (VI).