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ChemInform Abstract: A 4-Hydroxypyrrolidine-Catalyzed Mannich Reaction of Aldehydes: Control of anti-Selectivity by Hydrogen Bonding Assisted by Broensted Acids.

✍ Scribed by Enrique Gomez-Bengoa; Miguel Maestro; Antonia Mielgo; Itziar Otazo; Claudio Palomo; Irene Velilla


Publisher
John Wiley and Sons
Year
2010
Weight
29 KB
Volume
41
Category
Article
ISSN
0931-7597

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A 4-Hydroxypyrrolidine-Catalyzed Mannich
✍ Enrique Gómez-Bengoa; Miguel Maestro; Antonia Mielgo; Itziar Otazo; Claudio Palo 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 424 KB

## Abstract An __anti__‐selective Mannich reaction of aldehydes with __N__‐sulfonyl imines has been developed by using a 4‐hydroxypyrrolidine in combination with an external Brønsted acid. The catalyst design is based on three elements: the α‐substituent of the pyrrolidine, the 4‐hydroxy group, and