A 4-Hydroxypyrrolidine-Catalyzed Mannich
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Enrique Gómez-Bengoa; Miguel Maestro; Antonia Mielgo; Itziar Otazo; Claudio Palo
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Article
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2010
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John Wiley and Sons
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English
⚖ 424 KB
## Abstract An __anti__‐selective Mannich reaction of aldehydes with __N__‐sulfonyl imines has been developed by using a 4‐hydroxypyrrolidine in combination with an external Brønsted acid. The catalyst design is based on three elements: the α‐substituent of the pyrrolidine, the 4‐hydroxy group, and