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ChemInform Abstract: 4,5-Diaryloxazole Inhibitors of Cyclooxygenase-2 (COX-2)

✍ Scribed by John J. Talley; et al. et al.


Publisher
John Wiley and Sons
Year
2010
Weight
25 KB
Volume
30
Category
Article
ISSN
0931-7597

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A series of methysulfonyl or sulfonamido substituted 4,5-diaryloxazole were prepared and evaluated for their ability to inhibit the inducible form of cyclooxygenase (COX-2) in vitro and in vivo. Several unique substitution patterns were identified that led to potent and selective inhibitors of COX-2

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