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ChemInform Abstract: 4-Aryl-2-anilinopyrimidines as Corticotropin-Releasing Hormone (CRH) Antagonists.

✍ Scribed by Anthony J. Cocuzza; Frank W. Hobbs; Charles R. Arnold; Dennis R. Chidester; Jerry A. Yarem; Steven Culp; Lawrence Fitzgerald; Paul J. Gilligan

Publisher: John Wiley and Sons
Year: 2010
Weight: 33 KB
Volume: 30
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199932156

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✦ Synopsis

4-Aryl-2-anilinopyrimidines as Corticotropin-Releasing Hormone (CRH) Antagonists.

-A series of title compounds, e.g. (VII), (XI), and (XIV), are prepared by three different routes and tested for the desired biological activity. It is found that 2-phenyl substituted derivatives are the most potent ones, whereas the unsubstituted compound (XIVa) is equipotent to (XIVb). -(COCUZZA,

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