ChemInform Abstract: 4-Aminothiourea Prolinol tert-Butyldiphenylsilyl Ether: A Chiral Secondary Amine-Thiourea as Organocatalyst for Enantioselective anti-Mannich Reactions.

4-Aminothiourea Prolinol tert-Butyldiphe

4-Aminothiourea Prolinol tert-Butyldiphenylsilyl Ether: A Chiral Secondary Amine-Thiourea as Organocatalyst for Enantioselective anti-Mannich Reactions

✍ Hui Zhang; Yongming Chuan; Zhengyu Li; Yungui Peng 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 210 KB

## Abstract __anti__‐Selective Mannich reactions of __N__‐__p__‐methoxyphenyl (PMP)‐protected α‐iminoglyoxylate with unmodified aldehydes or ketones were effectively catalyzed by 4‐aminothiourea prolinol __tert__‐butyldiphenylsilyl ether. The reactions led to chiral β‐amino carbonyl compounds in hi