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ChemInform Abstract: 3-(Octadecanoylaminomethyl)indole-2-carboxylic Acid Derivatives and 1- Methyl-3-octadecanoylindole-2-carboxylic Acid as Inhibitors of Cytosolic Phospholipase A2.

✍ Scribed by M. LEHR

Publisher
John Wiley and Sons
Year
2010
Weight
31 KB
Volume
28
Category
Article
ISSN
0931-7597

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✦ Synopsis

1997 indole derivatives, isoindole derivatives indole derivatives, isoindole derivatives R 0140 04 -129 3-(Octadecanoylaminomethyl)indole-2-carboxylic Acid Derivatives and 1-Methyl-3-octadecanoylindole-2-carboxylic Acid as Inhibitors of Cytosolic Phospholipase A2.

-Indole-2-carboxylic acid derivatives with a 3-octadecanoylaminomethyl moiety (XI) or with a 3-octadecanoyl moiety (X) prove to be inhibitors of the title lipase. The acid (X) is so potent, that further investigations will follow. Acids of type (VIII) do not show any activity.

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ChemInform Abstract: Synthesis, Biologic
ChemInform Abstract: Synthesis, Biological Evaluation, and Structure-Activity Relationships of 3-Acylindole-2-carboxylic Acids as Inhibitors of the Cytosolic Phospholipase A2.
✍ M. LEHR πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons βš– 33 KB πŸ‘ 1 views

1997 indole derivatives, isoindole derivatives indole derivatives, isoindole derivatives R 0140 ## 49 -143 Synthesis, Biological Evaluation, and Structure-Activity Relationships of 3-Acylindole-2-carboxylic Acids as Inhibitors of the Cytosolic Phospholipase A2. -All title compounds are synthesize