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ChemInform Abstract: 10-Hydrocinnamoyl- and 10-Cinnamoyl-1,8-dihydroxy-9(10H)-anthracenones as Inhibitors of Leukotriene B4 Biosynthesis and HaCaT Cell Growth.

✍ Scribed by Klaus Mueller; Hans Reindl; Ingo Gawlik

Publisher
John Wiley and Sons
Year
2010
Weight
31 KB
Volume
30
Category
Article
ISSN
0931-7597

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✦ Synopsis

10-Hydrocinnamoyl-and 10-Cinnamoyl-1,8-dihydroxy-9(10H)anthracenones as Inhibitors of Leukotriene B 4 Biosynthesis and HaCaT Cell Growth. -Synthesis and biological evaluation of anthracenones bearing 10-hydrocinnamoyl and 10-cinnamoyl substituents are reported. Many compounds (III) are potent inhibitors of the growth of HaCaT cells with IC 50 values in the submicromolar range. -(MUELLER, KLAUS; REINDL,

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