ChemInform Abstract: 1-Oxa-3,8-diazaspiro(4.5)decan-2-one Derivatives with a Potent Inhibitory Effect on Neural Ca-Uptake and Protecting Action Against TET-Induced Brain Edema and Memory and Learning Deficits.
✍ Scribed by E. TOTH; B. KISS; A. GERE; E. KARPATI; J. TOERLEY; E. PALOSI; A. KIS-VARGA; M. PAROCZAI; S. SZABO; D. GROO; I. LASZLOVSZKY; E. LAPIS; K. CSOMOR; L. SZPORNY
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 31 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0931-7597
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✦ Synopsis
1-Oxa-3,8-diazaspiro(4.5)decan-2-one Derivatives with a Potent Inhibitory Effect on Neural Ca-Uptake and Protecting Action Against TET-Induced Brain Edema and Memory and Learning Deficits.
-The synthesis of 63 title compounds of type (I) is described. Among all tested representatives the derivatives (I) are found to be the most active inhibitors of neural Ca-uptake and protectors against triethyltin chloride induced brain edema. (Ib) is currently under preclinical development with the code name of