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ChemInform Abstract: 1-Methoxy-agroclavine from Penicillium sp. WC75209, a Novel Inhibitor of the Lck Tyrosine Kinase.

✍ Scribed by R. PADMANABHA; Y.-Z. SHU; L. S. COOK; J. A. VEITCH; M. DONOVAN; S. LOWE; S. HUANG; D. PIRNIK; S. P. MANLY


Publisher
John Wiley and Sons
Year
2010
Weight
29 KB
Volume
29
Category
Article
ISSN
0931-7597

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✦ Synopsis


1-Methoxy-agroclavine from Penicillium sp.

WC75209, a Novel Inhibitor of the Lck Tyrosine Kinase.

-The title compound (I) is a new member of the ergot alkaloid family and shows Lck tyrosine kinase inhibitory activity which seems to depend on the stereochemistry of the ring fusion points. -(