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ChemInform Abstract: 1-[(Benzofuran-2-yl)phenylmethyl]-triazoles and -tetrazoles. Potent Competitive Inhibitors of Aromatase.

✍ Scribed by T. K. Vinh; M. Ahmadi; P. O. Lopez Delgado; S. Fernandez Perez; H. M. Walters; H. J. Smith; P. J. Nicholls; C. Simons

Publisher: John Wiley and Sons
Year: 2010
Weight: 30 KB
Volume: 30
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199943125

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✦ Synopsis

1999 triazole derivatives triazole derivatives R 0280 43 -125 1-[(Benzofuran-2-yl)phenylmethyl]-triazoles and -tetrazoles. Potent Competitive Inhibitors of Aromatase.

-The synthesized triazoles (VIa), (VIb) show greater inhibition of human placental aromatase than tetrazoles (VIc), (VId). It is also shown that desired activity can be increased by phenyl substitution but decreased by benzofuran modifications. -(VINH,

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