Chemiluminescent flow-through sensor for automated dissolution testing of analgin tablets using manganese dioxide as oxidate
✍ Scribed by Lixia Zhao; Baoxin Li; Zhujun Zhang; Jin-Ming Lin
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 88 KB
- Volume
- 97
- Category
- Article
- ISSN
- 0925-4005
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✦ Synopsis
A chemiluminescence (CL) flow-through sensor for the determination of analgin was described. It was based on the direct oxidation of analgin by manganese dioxide to produce a weak CL in the absence of luminescence reagent. The CL intensity in acidic medium was enhanced by the addition of Rhodamine B (RhB). The solid-phase manganese dioxide was immobilized on the sponge rubber inside the CL flow cell by a very simple means. The calibration graph is linear in the range 4 × 10 -5 to 1 × 10 -3 g/ml with a detection limit of 2.7 × 10 -5 g/ml (S/N = 3). The sensor was successfully used for automated dissolution testing of analgin tablets and sampling frequency was 120 times/h. The dissolution profiles of analgin tablets from three different plants were obtained, which demonstrate the stability, sensitivity, large dynamic measuring range and robustness of the system.