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Chemiluminescence determination of fluoroquinolone antibiotics using a soluble manganese (IV)-sulphite system

✍ Scribed by Jianxiu Du; Yinhuan Li; Jiuru Lu

Publisher: John Wiley and Sons
Year: 2005
Tongue: English
Weight: 94 KB
Volume: 20
Category: Article
ISSN: 1522-7235
DOI: 10.1002/bio.798

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✦ Synopsis

The reaction of soluble manganese (IV) with sulphite in acidic condition was found to elicit weak chemiluminescence (CL). The CL signal was remarkably enhanced in the presence of three fluoroquinolones, viz. norfloxacin, ofloxacin and ciprofloxacin. Based on these observations, a new flow-injection CL method was developed for the determination of these fluoroquinolones. The method allows determination in the range 5.0 x 10(-8)-1.0 x 10(-6) mol/L for norfloxacin, 1.0 x 10(-7)-8.0 x 10(-6) mol/L for ofloxacin and 1.0 x 10(-7)-3.0 x 10(-5) mol/L for ciprofloxacin, with detection limits of 3 x 10(-8) mol/L, 5 x 10(-8) mol/L and 3 x 10(-8) mol/L, respectively. The method was applied to the determination of fluoroquinolones in pharmaceutical preparations.

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