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Chemico-enzymatic syntheses of racemic and chiral isomers of 7- methyl-1,6-dioxaspiro[4.5]decane

✍ Scribed by Sowmianarayanan Ramaswamy; Allan C. Oehlschlager

Publisher: Elsevier Science
Year: 1991
Tongue: French
Weight: 375 KB
Volume: 47
Category: Article
ISSN: 0040-4020
DOI: 10.1016/s0040-4020(01)86372-9

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✦ Synopsis

Porcine pancreatic lipase (PPL) mediated resolution of 6-heptene-2-ol afforded the enantiomers in high optical purities. Alkylation products of the dianion of the 2-4'-hydroxypentyl-1,3dithiane prepared from the enantiomers, followed by alkylative hydrolysis, afforded 97% optically pure E-7-methyl-1,6-dioxaspiro[4.5]decane.

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