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Chemically induced myotonia in amphibia

✍ Scribed by Bretag, A. H.; Dawe, S. R.; Moskwa, A. G.

Book ID
109719345
Publisher
Nature Publishing Group
Year
1980
Tongue
English
Weight
563 KB
Volume
286
Category
Article
ISSN
0028-0836

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## Background Slowed muscle relaxation is the contractile hallmark of myotonia congenita, a disease caused by genetic CLC-1 chloride channel deficiency, which improves with antecedent brief contractions ("warm-up phenomenon"). It is unclear to what extent the myotonia continues to dissipate during