๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Chemical synthesis of kurtoxin, a T-type calcium channel blocker

โœ Scribed by Hideki Nishio; Yuji Nishiuchi; Masanori Ishimaru; Terutoshi Kimura

Book ID
105576120
Publisher
Springer Netherlands
Year
2003
Tongue
English
Weight
622 KB
Volume
10
Category
Article
ISSN
1573-3149

No coin nor oath required. For personal study only.

๐Ÿ“œ SIMILAR VOLUMES

Solid-phase Synthesis of ฯ‰-Agatoxin IVA,
Solid-phase Synthesis of ฯ‰-Agatoxin IVA, a P-type Calcium Channel Blocker
โœ Jamila Najib; Thierry Letailleur; Jean-Claude Gesquiรจre; Andrรฉ Tartar ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 700 KB

omega-Agatoxin IVA, isolated from the venom of funnel web spider Agelenopsis aperta, blocks potently and selectively P-type calcium channels. This toxin, composed of 48 amino acids and containing 8 cysteine residues, was synthesized by the solid-phase procedure. The Cys residues were protected by ac

T-type calcium channel blockers: spiro-p
T-type calcium channel blockers: spiro-piperidine azetidines and azetidinonesโ€”optimization, design and synthesis
โœ Elizabeth M. Smith; Steve Sorota; Hyunjin M. Kim; Brian A. McKittrick; Terry L. ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 602 KB

A series of spiro-azetidines and azetidinones has been evaluated as novel blockers of the T-type calcium channel (Ca(V)3.2) which is a new therapeutic target for the potential treatment of both inflammatory and neuropathic pain. Confirmation and optimization of the potency, selectivity and DMPK prop