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Chemical synthesis and characterization of the epidermal growth factor-like module of human complement protease Clr

✍ Scribed by HERNANDEZ, JEAN-FRANÇOIS ;BERSCH, BEATE ;PÉTILLOT, YVES ;GAGNON, JEAN ;ARLAUD, GÉRARD J.


Book ID
110893538
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
949 KB
Volume
49
Category
Article
ISSN
1397-002X

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Human plasma protein S is a nonenzymatic cofactor for activated protein C (APC) in the inactivation of coagulation factors Va and VIIIa, and helps to provide an essential negative feedback on blood coagulation. Previous indirect evidence suggested that the thrombin-sensitive region (TSR: residues 47