Chemical synthesis of human protein S th
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Tilman M. Hackeng; Philip E. Dawson; Stephen B.H. Kent; John H. Griffin
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Article
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1998
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Wiley (John Wiley & Sons)
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English
⚖ 171 KB
Human plasma protein S is a nonenzymatic cofactor for activated protein C (APC) in the inactivation of coagulation factors Va and VIIIa, and helps to provide an essential negative feedback on blood coagulation. Previous indirect evidence suggested that the thrombin-sensitive region (TSR: residues 47