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Chemical stress relaxation of polyglycolic acid suture

โœ Scribed by Michael J. Hayes; Mark D. Lauren


Publisher
Wiley (John Wiley & Sons)
Year
1994
Tongue
English
Weight
382 KB
Volume
5
Category
Article
ISSN
1045-4861

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โœฆ Synopsis


Abstract

Chemical stress relaxation methods are employed to study chemical and mechanical factors influencing the degradation of uncoated polyglycolic acid (PG) sutures. Specially constructed instrumentation is used to study the kinetics of the load bearing capability of PG (Dexon^TM^) 3โ€0 sutures in hydrolytic solution. The effects of pH, temperature, strain rate, and initial load on the rate of chemical stress relaxation are presented. Data show how mechanical factors such as the rate of loading (related to the speed of knot tying), as well as the final tension, are related to the rate of structural degradation. Maximum stability is observed at approximately 40ยฐC, with slower degradation both above and below this point. Results show that the slower and tighter the suture is pulled, the greater its ability to sustain tensile loads during hydrolysis. ยฉ 1994 John Wiley & Sons, Inc.


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The purpose of the study was to examine the effect of gamma irradiation on the enzymatic as well as the in vivo degradation of polyglycolic acid sutures. The sutures of size 2-0 were irradiated at dosage levels of 0-20 mrad. The three enzymes chosen for this study were esterase, alpha-chymotrypsin,