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Chemical stabilization of a Δ9-tetrahydrocannabinol prodrug in polymeric matrix systems produced by a hot-melt method: Role of microenvironment pH

✍ Scribed by Manish Munjal; Mahmoud A. ElSohly; Michael A. Repka

Book ID
111767308
Publisher
Springer US
Year
2006
Tongue
English
Weight
503 KB
Volume
7
Category
Article
ISSN
1530-9932

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Polymeric systems for amorphous Δ9-tetra
Polymeric systems for amorphous Δ9-tetrahydrocannabinol produced by a hot-melt method. Part I: Chemical and thermal stability during processing
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The objective of the present research was to investigate the stability of an amorphous drug, Delta(9)-tetrahydrocannabinol (THC) in polymer-based transmucosal systems. THC was incorporated in polyethylene oxide and hydroxypropylcellulose matrices by a hot-melt fabrication procedure, utilizing variou

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✍ Manish Munjal; Mahmoud A. ElSohly; Michael A. Repka 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 203 KB

The objectives of the present research investigations were to (i) elucidate the mechanism for the oxidative degradation of Delta(9)-tetrahydrocannabinol (THC) in polymer matrix systems prepared by a hot-melt fabrication procedure, and (ii) study the potential for controlling these mechanisms to redu