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Chemical shift assignments and secondary structure of the surrogate domain for drug discovery studies of human heparanase

✍ Scribed by Mosulén, Silvia; Pineda-Lucena, Antonio; Carbajo, Rodrigo J.


Book ID
121460247
Publisher
Springer-Verlag
Year
2014
Tongue
English
Weight
743 KB
Volume
9
Category
Article
ISSN
1874-2718

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Chemical shift assignments and secondary
✍ Yu-Sen Wang; Anne F. Frederick; Mary M. Senior; Barbara A. Lyons; Stuart Black; 📂 Article 📅 1996 🏛 Springer Netherlands 🌐 English ⚖ 832 KB

The growth factor receptor-bound protein-2 (Grb2) is an adaptor protein that mediates signal transduction pathways. Chemical shift assignments were obtained for the SH2 domain of Grb2 by heteronuclear NMR spectroscopy, employing the uniformly 13C-/15N-enriched protein as well as the protein containi