✦ LIBER ✦
Chemical Shift Assignment of Geminal Protons in 3,7-Diazabicyclo[3.3.1]nonanes: An Unexpected Deviation from the Axial/Equatorial Chemical Shift Order
✍ Scribed by Adolf Gogoll; Helena Grennberg; Andreas Axén
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 314 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0749-1581
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✦ Synopsis
The chemical shift order of axial and equatorial methylene protons in 1,5-disubstituted 3,7diazabicyclo [ 3.3.1 ] nonan-9-ones may be altered by substituents in the 1,5-positions, but the corresponding alcohols behave di †erently. Unambiguous signal assignments for a series of the title compounds are provided, based on 3J CH coupling constants and on {1H} 13C heteronuclear Overhauser e †ects. Substituent anisotropy e †ects as a source of the chemical shift changes are discussed.