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Chemical Requirements for Inhibition of Gap Junction Communication by the Biologically Active Lipid Oleamide

✍ Scribed by Dale L. Boger, Jean E. Patterson, Xiaojun Guan, Benjamin F. Cravati, Richard A. Lerner and Norton B. Gilula


Book ID
123641201
Publisher
National Academy of Sciences
Year
1998
Tongue
English
Weight
955 KB
Volume
95
Category
Article
ISSN
0027-8424

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## Abstract The phorbol ester, 12‐__O__‐tetradecanoylphorbol‐13‐acetate (TPA), is a potent inhibitor of gap junctional intercellular communication (GJIC). This inhibition requires activation of protein kinase C (PKC), but the events downstream of this kinase are not known. Since PKC can activate ex