The number, position and orientation of nuclear OH substituents profoundly influence the equilibrium solubilities of undissociated bile acids in water. Estimates from several studies range from 5 x lo-' for lithocholic acid to 1.6 x
Chemical properties of bile acids: III. Bile acid structure and solubility in water
โ Scribed by A. Fini; A. Roda; R. Fugazza; B. Grigolo
- Publisher
- Springer US
- Year
- 1985
- Tongue
- English
- Weight
- 463 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0095-9782
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N-nitrosoamides of 713-hydroxylated bile acid conjugates, particularly of the ursodeoxycholic acid family have been scnthesized. The products and synthetic intermediates were fully characterized by the results of high-resolution IH NMR, FT-IR, t'ABMS and ESI-MS studies. The compounds, N-nitrosoglyco
Bile acid synthesis is believed to be regulated by bile salts returning to the liver via the portal vein and suppressing cholesterol 7a-hydroxylase, the rate-limiting enzyme in the bile acid biosynthesis pathway. In order to characterize the relative effectiveness of bile salts in regulating bile ac