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Chemical Pathways of Degradation of the Bradykinin Analog, RMP-7

โœ Scribed by Julie Ann Straub; Alan Akiyama; Parul Parmar; Gary F. Musso

Book ID
110346279
Publisher
Springer US
Year
1995
Tongue
English
Weight
632 KB
Volume
12
Category
Article
ISSN
0724-8741

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๐Ÿ“œ SIMILAR VOLUMES

Bromination and subsequent catalytic tri
Bromination and subsequent catalytic tritiation of thienylalanine and 4-methyltyrosine residues in the bradykinin analog RMP-7
โœ Alan Akiyama; Gary F. Musso; Janet L. Smart; Christopher Lang; Julie Ann Straub ๐Ÿ“‚ Article ๐Ÿ“… 1994 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 538 KB

## Abstract A two step strategy was devised for the synthesis of ^3^Hโ€RMPโ€7 for use in pharmacokinetic studies. First, RMPโ€7 was brominated predominantly on the thiophene ring of thienylalanine using Br~2~ in AcOH. Then, reductive tritiation of the brominated RMPโ€7 using ^3^H~2~ and Pd/C yielded ^3