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Chemical modification of triplex-forming oligonucleotide to promote pyrimidine motif triplex formation at physiological pH

โœ Scribed by Hidetaka Torigoe; Osamu Nakagawa; Takeshi Imanishi; Satoshi Obika; Kiyomi Sasaki


Book ID
116309539
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
680 KB
Volume
94
Category
Article
ISSN
0300-9084

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## Abstract Due to the instability of pyrimidine motif triplex DNA at physiological pH, triplex stabilization at physiological pH is crucial in improving its potential in various triplexโ€formationโ€based strategies in vivo, such as gene expression regulation, genomic DNA mapping, and geneโ€targeted m