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Chemical modification of the carboxyl groups of protein substrates enhances their thrombin susceptibility

✍ Scribed by Verena Steiner; Jui-Yoa Chang


Book ID
115919053
Publisher
Elsevier Science
Year
1987
Tongue
English
Weight
432 KB
Volume
222
Category
Article
ISSN
0014-5793

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The usefulness of ricin as a research tool is handicapped by its extremely biohazardous nature. In this work, ricin toxicity has been reduced by chemical modification of carboxyl groups using 1-ethyl-3(3-dimethylaminopropyl) carbodiimide and [14C]glycine methyl ester. The reaction was carried out in